Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood
The American Journal of Psychiatry
Fecha de publicación: 12 January 2018
Autores: Sarah J. Marzi, Ph.D., Karen Sugden, Ph.D., Louise Arseneault, Ph.D., Daniel W. Belsky, Ph.D., Joe Burrage, Ph.D., David L. Corcoran, Ph.D., Andrea Danese, M.D., Ph.D., Helen L. Fisher, Ph.D., Eilis Hannon, Ph.D., Terrie E. Moffitt, Ph.D., Candice L. Odgers, Ph.D., Carmine Pariante, M.D., Ph.D., Richie Poulton, Ph.D., Benjamin S. Williams, B.Sc., Chloe C.Y. Wong, Ph.D., Jonathan Mill, Ph.D., Avshalom Caspi, Ph.D.
Background: DNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become “embedded” in the genome and alter transcriptional processes to compromise health. The authors sought to investigate whether early-life victimization stress is associated with genome-wide DNA methylation.