C-reactive protein and efficacy of antiplatelet therapy in (intracranial) atherosclerosis

Neurology Journal 

Fecha de publicación: 12 January 2018

DOI: https://doi.org/10.1212/WNL.0000000000004937

Autores: Antonino Tuttolomondo, Antonio Pinto

Background: C-reactive protein (CRP) and other inflammatory biomarkers can indicate both the severity and extent of atherosclerosis, reflecting the inflammatory nature of the disease process.1 Atherogenesis begins with an inflammatory response to vascular injury with cells and mediators initiating the healing response and later inducing growth of atherosclerotic plaques. Inflammation then increases plaque instability, promoting rupture, fissuring, or erosion—the pathogenetic milieu of thrombosis in atherothrombotic ischemic strokes.

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