Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

The Lancet Neurology

Fecha de publicación: January 2018

DOI: http://dx.doi.org/10.1016/S1474-4422(17)30407-6

Autores: Wim H van Zwam, MD, Prof Mayank Goyal, MD, Bijoy K Menon, MD, Prof Diederik W J Dippel, MD, Prof Andrew M Demchuk, MD, Prof Serge Bracard, MD, Prof Philip White, MD, Prof Antoni Dávalos, MD, Prof Charles B L M Majoie, PhD, Prof Aad van der Lugt, MD, Gary A Ford, FRCP, Natalia Pérez de la Ossa, MD, Prof Michael Kelly, PhD, Romain Bourcier, PhD, Prof Geoffrey A Donnan, MD, Prof Yvo B W E M Roos, PhD, Prof Oh Young Bang, MD, Bruce C V Campbell, PhD

Objective: General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care.