American Journal of Psychiatry
Fecha de publicación: 6 May 2019
Autores: Leslie G. Nucifora , Ph.D., Matthew L. MacDonald , Ph.D., Brian J. Lee , B.S., Matthew E. Peters , M.D., Alexis L. Norris , Ph.D., Benjamin C. Orsburn , Ph.D., Kun Yang , Ph.D., Kelly Gleason , M.S., Russell L. Margolis, et al.
Background: The mechanisms leading to schizophrenia are likely to be diverse. However, there may be common pathophysiological pathways for subtypes of the disease. The authors tested the hypothesis that increased protein insolubility and ubiquitination underlie the pathophysiology for a subtype of schizophrenia.