Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study
The Lancet Neurology
Fecha de publicación: 14 november 2018
Autores: Peter J Lally, PhD., Paolo Montaldo, MBBS., Vânia Oliveira, MSc., Aung Soe, FRCPCH., Ravi Swamy, MD., Paul Bassett, MSc., et al.
Background: In neonatal encephalopathy, the clinical manifestations of injury can only be reliably assessed several years after an intervention, complicating early prognostication and rendering trials of promising neuroprotectants slow and expensive. We aimed to determine the accuracy of thalamic proton magnetic resonance (MR) spectroscopy (MRS) biomarkers as early predictors of the neurodevelopmental abnormalities observed years after neonatal encephalopathy.