Maternal Bacterial Infection During Pregnancy and Offspring Risk of Psychotic Disorders: Variation by Severity of Infection and Offspring Sex
American Journal of Psychiatry
Fecha de publicación: 4 Octubre 2019
Autores: Younga H. Lee, Ph.D., Sara Cherkerzian, Sc.D., Larry J. Seidman, Ph.D., George D. Papandonatos, Ph.D., David A. Savitz, Ph.D., Ming T. Tsuang, M.D., Ph.D., Jill M. Goldstein, Ph.D., Stephen L. Buka, Sc.D.
Background: Previous studies suggest that prenatal immune challenges may elevate the risk of schizophrenia and related psychoses in offspring, yet there has been limited research focused on maternal bacterial infection. The authors hypothesized that maternal bacterial infection during pregnancy increases offspring risk of psychotic disorders in adulthood, and that the magnitude of this association varies as a function of severity of infectious exposure and offspring sex.