Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis
Journal of Neurology, Neurosurgery & Psychiatry
Fecha de publicación: 14 August 2019
Autores: Roisin McMackin, Muthuraman Muthuraman, Sergiu Groppa, Claudio Babiloni, John-Paul Taylor, Matthew C Kiernan, Bahman Nasseroleslami, Orla Hardiman.
Background: Advanced neuroimaging has increased understanding of the pathogenesis and spread of disease, and offered new therapeutic targets. MRI and positron emission tomography have shown that neurodegenerative diseases including Alzheimer’s disease (AD), Lewy body dementia (LBD), Parkinson’s disease (PD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are associated with changes in brain networks.