Polygenic Risk: Predicting Depression Outcomes in Clinical and Epidemiological Cohorts of Youths
American Journal of Psychiatry
Fecha de publicación: 5 April 2019
Autores: Thorhildur Halldorsdottir , Ph.D., Charlotte Piechaczek , M.S., Ana Paula Soares de Matos , Ph.D., Darina Czamara , Ph.D., Verena Pehl , Ph.D., et al.
Background: Identifying risk factors for major depression and depressive symptoms in youths could have important implications for prevention efforts. This study examined the association of polygenic risk scores (PRSs) for a broad depression phenotype derived from a large-scale genome-wide association study (GWAS) in adults, and its interaction with childhood abuse, with clinically relevant depression outcomes in clinical and epidemiological youth cohorts.