Prevalence, predictors, and prognosis of symptomatic intracranial stenosis in patients with transient ischaemic attack or minor stroke: a population-based cohort study
The Lancet Neurology
Fecha de publicación: 1 May 2020
Autores: Robert Hurford, MRCP., Frank J Wolters, PhD., Linxin Li, DPhil., Kui Kai Lau, DPhil., Wilhelm Küker, MD., Prof Peter M Rothwell, FMedSci., et al.
Background: Symptomatic intracranial stenosis was perceived to convey a high risk of recurrent stroke, but two previous trials (SAMMPRIS and VISSIT) did not show superiority of intracranial stenosis stenting over intensive medical management alone. These findings were partly due to a lower than expected risk of recurrent stroke without stenting, possibly reflecting the young age of recruits (median age <60 years), and raise questions about generalisability to routine clinical practice. We therefore studied the age-specific prevalence, predictors, and prognosis of symptomatic intracranial stenosis in a population-based cohort of patients with transient ischaemic attack and minor stroke on intensive medical management.