The Lancet Journal
Fecha de publicación: 1 september 2018
Autores: Aurora Scrivo, PhD. Mathieu Bourdenx, PhD. Olatz Pampliega, PhD. Prof Ana Maria Cuervo, PhD
Background: Cells rely on surveillance systems such as autophagy to handle protein alterations and organelle damage. Dysfunctional autophagy, an evolutionarily conserved cellular mechanism for degradation of intracellular components in lysosomes, frequently leads to neurodegeneration. The neuroprotective effect of autophagy stems from its ability to eliminate pathogenic forms of proteins such as α-synuclein or tau. However, the same pathogenic proteins often affect different types and steps of the autophagic process.