The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study
The Lancet Psychiatry
Fecha de publicación: 20 september 2018
Autores: Laurie J Hannigan, PhD., Espen Moen Eilertsen, PhD., Line C Gjerde, PhD., Ted Reichborn-Kjennerud, MD., Prof Thalia C Eley, PhD., Fruhling V Rijsdijk, PhD., Eivind Ystrom, PhD., Tom A McAdams, PhD
Background: The pathophysiology of psychosis is incompletely understood. Disruption in cortical glutamatergic signalling causing aberrant striatal dopamine synthesis capacity is a proposed model for psychosis, but has not been tested in vivo. We therefore aimed to test the relationship between cortical glutamate concentrations and striatal dopamine synthesis capacity, and psychotic symptoms.