Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis
The Lancet Psychiatry
Volume 4, No. 4, p295–301, April 2017
Dr Carsten Hjorthøj, Anne Emilie Stürup, MD, Prof John J McGrath, PhD, Prof Merete Nordentoft, DMSc
Abstract
Background
Several studies and meta-analyses have shown that mortality in people with schizophrenia is higher than that in the general population but have used relative measures, such as standardised mortality ratios. We did a systematic review and meta-analysis to estimate years of potential life lost and life expectancy in schizophrenia, which are more direct, absolute measures of increased mortality.
Methods
We searched MEDLINE, PsycINFO, Embase, Cinahl, and Web of Science for published studies on years of potential life lost and life expectancy in schizophrenia. Data from individual studies were combined in meta-analyses as weighted averages. We did subgroup analyses for sex, geographical region, timing of publication, and risk of bias (estimated with the Newcastle-Ottawa Scale).
