A compound heterozygous PINK1-associated juvenile Parkinson’s disease with pregnancy in Chinese

Neurology Journal

Fecha de publicación: 21 de enero de 2021

Autores: Jun-ying Li, Nan-nan Li, Ling Wang, Jia-xin Peng, Li-ren Duan, Chao-lan Chen & Rong Peng

DOI: https://doi.org/10.1007/s00415-021-10405-z

Background: PINK1 mutations are the second most common cause of recessive, early-onset Parkinson’s disease (EOPD), of which 15% are cases of juvenile PD. PD is a progressive neurological disease that primarily affects middle-aged and older people. Thus PD patients experiencing pregnancy is uncommon, especially in patients with juvenile PD caused by PINK1 mutations. We are first to report a woman from a Chinese family diagnosed with sporadic juvenile PD and treated with levodopa/benserazide throughout pregnancy.