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Accelerated Gray and White Matter Deterioration With Age in Schizophrenia

3/4/2017

The American Journal of Psichiatry
Volume 174, Issue 3, March 01, 2017, pp. 286-295

Vanessa L. Cropley, Ph.D., Paul Klauser, M.D., Ph.D., Rhoshel K. Lenroot, M.D., Jason Bruggemann, Ph.D., Suresh Sundram, M.B.B.S., Ph.D., Chad Bousman, Ph.D., Avril Pereira, Ph.D., Maria A. Di Biase, B.S., Thomas W. Weickert, Ph.D., Cynthia Shannon Weickert, Ph.D., Christos Pantelis, M.B.B.S., M.D., Andrew Zalesky, Ph.D.

Abstract

Objective:

Although brain changes in schizophrenia have been proposed to mirror those found with advancing age, the trajectory of gray matter and white matter changes during the disease course remains unclear. The authors sought to measure whether these changes in individuals with schizophrenia remain stable, are accelerated, or are diminished with age.

Method:
Gray matter volume and fractional anisotropy were mapped in 326 individuals diagnosed with schizophrenia or schizoaffective disorder and in 197 healthy comparison subjects aged 20–65 years. Polynomial regression was used to model the influence of age on gray matter volume and fractional anisotropy at a whole-brain and voxel level. Between-group differences in gray matter volume and fractional anisotropy were regionally localized across the lifespan using permutation testing and cluster-based inference.

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Esquizofrenia • Psiquiatría