Accelerated Gray and White Matter Deterioration With Age in Schizophrenia

The American Journal of Psichiatry
Volume 174, Issue 3, March 01, 2017, pp. 286-295

Vanessa L. Cropley, Ph.D., Paul Klauser, M.D., Ph.D., Rhoshel K. Lenroot, M.D., Jason Bruggemann, Ph.D., Suresh Sundram, M.B.B.S., Ph.D., Chad Bousman, Ph.D., Avril Pereira, Ph.D., Maria A. Di Biase, B.S., Thomas W. Weickert, Ph.D., Cynthia Shannon Weickert, Ph.D., Christos Pantelis, M.B.B.S., M.D., Andrew Zalesky, Ph.D.


Gray matter volume and fractional anisotropy were mapped in 326 individuals diagnosed with schizophrenia or schizoaffective disorder and in 197 healthy comparison subjects aged 20–65 years. Polynomial regression was used to model the influence of age on gray matter volume and fractional anisotropy at a whole-brain and voxel level. Between-group differences in gray matter volume and fractional anisotropy were regionally localized across the lifespan using permutation testing and cluster-based inference.


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