Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer’s disease: a cross-sectional study

The Lancet Neurology

Fecha de publicación: February 2018


Autores: Philip S J Weston, MRCP, Jennifer M Nicholas, PhD, Susie M D Henley, PhD, Yuying Liang, MRCP, Kirsty Macpherson, BA, Elizabeth Donnachie, BA, Prof Jonathan M Schott, FRCP, Prof Martin N Rossor, FMedSci, Prof Sebastian J Crutch, PhD, Christopher R Butler, FRCP, Prof Adam Z Zeman, FRCP, Prof Nick C Fox, FMedSci

Objective: Tests sensitive to presymptomatic changes in Alzheimer’s disease could be valuable for clinical trials. Accelerated long-term forgetting—during which memory impairment becomes apparent over longer periods than usually assessed, despite normal performance on standard cognitive testing—has been identified in other temporal lobe disorders. We assessed whether accelerated long-term forgetting is a feature of presymptomatic autosomal dominant (familial) Alzheimer’s disease, and whether there is an association between accelerated long-term forgetting and early subjective memory changes.


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