Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex

Gerontology Journal

Fecha de publicación: 5 de octubre de 2021

Autores: Elise S Bisset, MSc, Stefan Heinze-Milne, MSc, Scott A Grandy, PhD, Susan E Howlett, PhD

DOI: https://doi.org/10.1093/gerona/glab297

Background: Aerobic exercise is a promising intervention to attenuate frailty, but preclinical studies have used only male animals. We investigated the impact of voluntary aerobic exercise on frailty, biological age (FRailty Inferred Geriatric Health Timeline [FRIGHT] clock)…