Altered Cellular White Matter But Not Extracellular Free Water on Diffusion MRI in Individuals at Clinical High Risk for Psychosis

American Journal of Psychiatry

Fecha de publicación: 24 June 2019


Autores: Yingying Tang , Ph.D., Ofer Pasternak , Ph.D., Marek Kubicki , M.D., Ph.D., Yogesh Rathi , Ph.D., Tianhong Zhang , M.D., Ph.D., Junjie Wang , Ph.D., Huijun Li , Ph.D., Kristen A. Woodberry , M.S.W., Ph.D., Lihua Xu, Ph.D., et al.

Background: Detecting brain abnormalities in clinical high-risk populations before the onset of psychosis is important for tracking pathological pathways and for identifying possible intervention strategies that may impede or prevent the onset of psychotic disorders. Co-occurring cellular and extracellular white matter alterations have previously been implicated after a first psychotic episode. The authors investigated whether or not cellular and extracellular alterations are already present in a predominantly medication-naive cohort of clinical high-risk individuals experiencing attenuated psychotic symptoms.

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