Neurology Journal
Fecha de publicación: 15 September 2017
DOI: http://dx.doi.org/10.1212/WNL.0000000000004516
Autores: Ron Shamir, PhD*, Christine Klein, MD*,†, David Amar, PhD*, Eva-Juliane Vollstedt, MD, Michael Bonin, PhD, Marija Usenovic, PhD, Yvette C. Wong, PhD, Ales Maver, MD, PhD, Sven Poths, Hershel Safer, PhD, Jean-Christophe Corvol, MD, PhD, Suzanne Lesage, PhD, Ofer Lavi, MSc, Günther Deuschl, MD, PhD, Gregor Kuhlenbaeumer, MD, PhD, Heike Pawlack, BSc, Igor Ulitsky, PhD, Meike Kasten, MD, Olaf Riess, MD, Alexis Brice, MD, Borut Peterlin, MD, PhD† and Dimitri Krainc, MD, PhD†
Objective: To examine whether gene expression analysis of a large-scale Parkinson disease (PD) patient cohort produces a robust blood-based PD gene signature compared to previous studies that have used relatively small cohorts (≤220 samples).