Association between midlife dementia risk factors and longitudinal brain atrophy: the PREVENT-Dementia study
Journal of Neurology, Neurosurgery & Psychiatry
Fecha de publicación: 10 January 2020
Autores: John T O’Brien, Michael J Firbank, Karen Ritchie, Katie Wells, Guy B Williams, Craig W Ritchie, Li Su
Background: Increased rates of brain atrophy on serial MRI are frequently used as a surrogate marker of disease progression in Alzheimer’s disease and other dementias. However, the extent to which they are associated with future risk of dementia in asymptomatic subjects is not clear. In this study, we investigated the relationship between the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) risk score and longitudinal atrophy in middle-aged subjects.