Associations between life-course-persistent antisocial behaviour and brain structure in a population-representative longitudinal birth cohort

The Lancet Psychiatry

Fecha de publicación: 17 February 2020


Autores: Christina O Carlisi, PhD., Prof Terrie E Moffitt, PhD., Annchen R Knodt, MSc., Honalee Harrington, BA
David Ireland, PhD., Tracy R Melzer, PhD., et al.

Background: Studies with behavioural and neuropsychological tests have supported the developmental taxonomy theory of antisocial behaviour, which specifies abnormal brain development as a fundamental aspect of life-course-persistent antisocial behaviour, but no study has characterised features of brain structure associated with life-course-persistent versus adolescence-limited trajectories, as defined by prospective data. We aimed to determine whether life-course-persistent antisocial behaviour is associated with neurocognitive abnormalities by testing the hypothesis that it is also associated with brain structure abnormalities.

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