Associations between plasma fatty acid concentrations and schizophrenia: a two-sample Mendelian randomisation study

Lancet Psychiatry

Fecha de publicación: 1 de diciembre de 2021

Autores: Hannah J Jones, PhD , Maria Carolina Borges, PhD, Rebecca Carnegie, MRCPsych, David Mongan, MBBCh, Prof Peter J Rogers, PhD, Prof Sarah J Lewis, PhD, Prof Andrew D Thompson, MBBS, Prof Stanley Zammit, MD

DOI: https://doi.org/10.1016/S2215-0366(21)00286-8

Background: Although studies suggest that concentrations of omega-3 and omega-6 fatty acids are lower in individuals with schizophrenia, evidence for beneficial effects of fatty acid supplementation is scarce. Therefore, in this study, we aimed to determine whether omega-3 and omega-6 fatty acid concentrations are causally related to schizophrenia.