Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer’s disease
Journal of Neurology, Neurosurgery & Psychiatry
Fecha de publicación: Abril de 2021
Autores: Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Deniz Yilmazer-Hanke, Sarah Anderl-Straub, Christine von Arnim, Lutz Froelich, Luis Aragão Gomes, Lucrezia Hausner, Andre Huss, Holger Jahn, Jochen Weishaupt, Albert C Ludolph, Dietmar R Thal, Markus Otto
Background: Synaptic loss plays a major role in Alzheimer’s disease (AD). However so far no neurochemical marker for synaptic loss has been introduced into clinical routine. By mass spectrometry beta-synuclein was established as a candidate marker. We now aimed to set up a novel ELISA for beta-synuclein for evaluation of its potential as a diagnostic and predictive marker for AD.