A Brain Model of Disturbed Self-Appraisal in Depression

The American Journal of Psychiatry

Published: September 2017
DOI: https://doi.org/10.1176/appi.ajp.2017.16080883
Autores: Christopher G. Davey, M.D., Ph.D., Michael Breakspear, M.D., Ph.D., Jesus Pujol, M.D., Ph.D., Ben J. Harrison, Ph.D.

Objective: A disturbed sense of self is a core feature of depression. The medial prefrontal cortex, which has a central role in self-appraisal processes, is often implicated in the illness, although it remains unclear how functional alterations of the region contribute to the observed disturbances…

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