Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging

Journal of the American Geriatrics Society
21 November 2016

Alexandra M. V. Wennberg PhD, Rodolfo Savica MD, PhD, Clinton E. Hagen MS, Rosebud O. Roberts MB, ChB, MS, David S. Knopman MD, John H. Hollman PhD, Prashanthi Vemuri PhD, Clifford R. Jack Jr MD, Ronald C. Petersen MD, PhD, Michelle M. Mielke PhD


Objective: To determine the cross-sectional association between cerebral amyloid-beta (Aβ) deposition and gait.

Design: Cross-sectional.

Setting: Population-based cohort study in Olmsted County, MN.

Participants: Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled in the Mayo Clinic Study of Aging with concurrent PiB-PET imaging and gait assessment. Participants with a history of stroke, alcoholism, Parkinson’s disease, subdural hematoma, traumatic brain injury, or normal pressure hydrocephalus were excluded…

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