Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia

Neurology Journal

Published online: 17 Mayo, 2017
DOI: http:/​/​dx.​doi.​org/​10.​1212/​WNL.​0000000000004034

AutoresLucia A.A. Giannini, BSc, David J. Irwin, MD, Corey T. McMillan, PhD, Sharon Ash, PhD, Katya Rascovsky, PhD, David A. Wolk, MD, Vivianna M. Van Deerlin, MD, PhD, Edward B. Lee, MD, PhD, John Q. Trojanowski, MD, PhD and Murray Grossman, MD

To determine whether logopenic features of phonologic loop dysfunction reflect Alzheimer disease (AD) neuropathology in primary progressive aphasia (PPA). We performed a retrospective case-control study of 34 patients with PPA with available autopsy tissue. We compared baseline and longitudinal clinical features in patients with primary AD neuropathology to those with primary non-AD pathologies. We analyzed regional neuroanatomic disease burden in pathology-defined groups using postmortem neuropathologic data.

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