Defining functional brain networks underlying obsessive–compulsive disorder (OCD) using treatment-induced neuroimaging changes: a systematic review of the literature

Journal of Neurology, Neurosurgery & Psychiatry

Fecha de publicación: 27 de abril de 2021

DOI: 10.1136/jnnp-2020-324478

Autores: Kelly R. Bijanki, Yagna J. Pathak, Ricardo A. Najera, Eric A. Storch, Wayne K Goodman, H. Blair Simpson, Sameer A. Sheth

Background: Approximately 2%–3% of the population suffers from obsessive–compulsive disorder (OCD). Several brain regions have been implicated in the pathophysiology of OCD, but their various contributions remain unclear. We examined changes in structural and functional neuroimaging before and after a variety of therapeutic interventions as an index into identifying the underlying networks involved. We identified 64 studies from 1990 to 2020 comparing pretreatment and post-treatment imaging of patients with OCD, including metabolic and perfusion, neurochemical, structural, functional and connectivity-based modalities. Treatment class included pharmacotherapy, cognitive–behavioural therapy/exposure and response prevention, stereotactic lesions, deep brain stimulation and transcranial magnetic stimulation.