Dissecting premotor Parkinson’s disease with multimodality neuroimaging

The Lancet Neurology

Fecha de publicación: 01 June 2018

DOI: https://doi.org/10.1016/S1474-4422(18)30196-0

Autores: Alex Iranzo

Background: Parkinson’s disease is diagnosed when parkinsonism (ie, bradykinesia, rigidity, and resting tremor) is clinically apparent. Parkinsonism manifests when a dopaminergic deficit of about 80% is present in the striatum due to neuronal loss of about 60% in the substantia nigra pars compacta.


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