The Lancet Neurology
Fecha de publicación: 01 June 2018
Autores: Alex Iranzo
Background: Parkinson’s disease is diagnosed when parkinsonism (ie, bradykinesia, rigidity, and resting tremor) is clinically apparent. Parkinsonism manifests when a dopaminergic deficit of about 80% is present in the striatum due to neuronal loss of about 60% in the substantia nigra pars compacta.