Effect of Experimental Manipulation of the Orbitofrontal Cortex on Short-Term Markers of Compulsive Behavior: A Theta Burst Stimulation Study

American Journal of Psychiatry

Fecha de publicación: 17 de marzo de 2021

DOI: https://doi.org/10.1176/appi.ajp.2020.20060821

Autores: Rebecca B. Price, Ph.D., Claire M. Gillan, Ph.D., Colleen Hanlon, Ph.D., Fabio Ferrarelli, M.D., Ph.D., Tae Kim, Ph.D., Helmet T. Karim, Ph.D., Marlee Renard, B.A., Rachel Kaskie, B.S., Michelle Degutis, B.S., Anna Wears, B.A., Emelina P. Vienneau, B.S.E., Angel V. Peterchev, Ph.D., Vanessa Brown, Ph.D., Greg J. Siegle, Ph.D., Meredith L. Wallace, Ph.D., Susanne E. Ahmari, M.D., Ph.D.

Background: Compulsive behaviors are a core feature of obsessive-compulsive spectrum disorders but appear across a broad spectrum of psychological conditions. It is thought that compulsions reflect a failure to override habitual behaviors “stamped in” through repeated practice and short-term distress reduction. Animal models suggest a possible causal role of the orbitofrontal cortex (OFC) in compulsive behaviors, but human studies have largely been limited by correlational designs. The goal of this study was to establish the first experimental evidence in humans for a mechanistic model in order to inform further experimental work and the eventual development of novel mechanistic treatments involving synergistic biological-behavioral pairings.

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