Effect of Intrinsic Patterns of Functional Brain Connectivity in Moderating Antidepressant Treatment Response in Major Depression

American Journal of Psychiatry

Fecha de publicación: 20 September 2019

DOI: https://doi.org/10.1176/appi.ajp.2019.18070870

Autores: Cherise R. Chin Fatt, Ph.D., Manish K. Jha, M.B.B.S., Crystal M. Cooper, Ph.D., Gregory Fonzo, Ph.D., Charles South, Ph.D., Bruce Grannemann, M.A., Thomas Carmody, Ph.D., et al.

Background: Major depressive disorder is associated with aberrant resting-state functional connectivity across multiple brain networks supporting emotion processing, executive function, and reward processing. The purpose of this study was to determine whether patterns of resting-state connectivity between brain regions predict differential outcome to antidepressant medication (sertraline) compared with placebo.

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