Effect of Intrinsic Patterns of Functional Brain Connectivity in Moderating Antidepressant Treatment Response in Major Depression
American Journal of Psychiatry
Fecha de publicación: 20 September 2019
Autores: Cherise R. Chin Fatt, Ph.D., Manish K. Jha, M.B.B.S., Crystal M. Cooper, Ph.D., Gregory Fonzo, Ph.D., Charles South, Ph.D., Bruce Grannemann, M.A., Thomas Carmody, Ph.D., et al.
Background: Major depressive disorder is associated with aberrant resting-state functional connectivity across multiple brain networks supporting emotion processing, executive function, and reward processing. The purpose of this study was to determine whether patterns of resting-state connectivity between brain regions predict differential outcome to antidepressant medication (sertraline) compared with placebo.