Evidence for Dopamine Abnormalities in the Substantia Nigra in Cocaine Addiction Revealed by Neuromelanin-Sensitive MRI
American Journal of Psychiatry
Fecha de publicación: 28 Aug 2020
DOI: https://doi.org/10.1176/appi.ajp.2020.20010090
Autores: Clifford M. Cassidy, Ph.D., Kenneth M. Carpenter, Ph.D., Anna B. Konova, Ph.D., Victoria Cheung, B.Sc., Alexander Grassetti, B.A., Luigi Zecca, M.D., Ph.D., Anissa Abi-Dargham, M.D., Diana Martinez, M.D., Guillermo Horga, M.D., Ph.D.
Background: Recent evidence supports the use of neuromelanin-sensitive MRI (NM-MRI) as a novel tool to investigate dopamine function in the human brain. The authors investigated the NM-MRI signal in individuals with cocaine use disorder, compared with age- and sex-matched control subjects, based on previous imaging studies showing that this disorder is associated with blunted presynaptic striatal dopamine.
