Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia

American Journal of Psychiatry

Fecha de publicación: 5 June 2019

DOI: https://doi.org/10.1176/appi.ajp.2019.18040380

Autores: Cassandra M.J. Wannan , B.App.Sc.(Hons), Vanessa L. Cropley , Ph.D., M. Mallar Chakravarty , Ph.D., Chad Bousman , Ph.D., Eleni P. Ganella , Ph.D., Jason M. Bruggemann , Ph.D., Thomas W. Weickert, et al.

Background: Cortical thickness reductions in schizophrenia are irregularly distributed across multiple loci. The authors hypothesized that cortical connectivity networks would explain the distribution of cortical thickness reductions across the cortex, and, specifically, that cortico-cortical connectivity between loci with these reductions would be exceptionally strong and form an interconnected network. This hypothesis was tested in three cross-sectional schizophrenia cohorts: first-episode psychosis, chronic schizophrenia, and treatment-resistant schizophrenia.

Seguir leyendo

Enviar comentario