Extra-axial cerebrospinal fluid in high-risk and normal-risk children with autism aged 2–4 years: a case-control study

Lancet Psychiatry

Fecha de publicación: 27 september 2018

DOI: https://doi.org/10.1016/S2215-0366(18)30294-3

Autores: Mark D Shen, PhD., Christine W Nordahl, PhD., Deana D Li, MPH., Aaron Lee, BS., Kathleen Angkustsiri, MD., Robert W Emerson, PhD., et al.

Background: We previously showed, in two separate cohorts, that high-risk infants who were later diagnosed with autism spectrum disorder had abnormally high extra-axial cerebrospinal fluid (CSF) volume from age 6–24 months. The presence of increased extra-axial CSF volume preceded the onset of behavioural symptoms of autism and was predictive of a later diagnosis of autism spectrum disorder. In this study, we aimed to establish whether increased extra-axial CSF volume is found in a large, independent sample of children diagnosed with autism spectrum disorder, whether extra-axial CSF remains abnormally increased beyond infancy, and whether it is present in both normal-risk and high-risk children with autism.

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