Forecasting seizure risk in adults with focal epilepsy: a development and validation study

The Lancet Neurology

Fecha de publicación: 17 de diciembre de 2020

DOI: https://doi.org/10.1016/S1474-4422(20)30396-3

Autores: Timothée Proix, PhD, Wilson Truccolo, PhD, Marc G Leguia, PhD, Thomas K Tcheng, PhD, David King-Stephens, MD, Vikram R Rao, MD ^†, Maxime O Baud, MD

Background

People with epilepsy are burdened with the apparent unpredictability of seizures. In the past decade, converging evidence from studies using chronic EEG (cEEG) revealed that epileptic brain activity shows robust cycles, operating over hours (circadian) and days (multidien). We hypothesised that these cycles can be leveraged to estimate future seizure probability, and we tested the feasibility of forecasting seizures days in advance.