GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores
American Journal of Psychiatry
Fecha de publicación: 5 June 2019
Autores: Niamh Mullins, Ph.D., Tim B. Bigdeli, Ph.D., Anders D. Børglum, Ph.D., Jonathan R.I. Coleman, Ph.D., Ditte Demontis, Ph.D., Divya Mehta, Ph.D., Robert A. Power, Ph.D., Stephan Ripke, Ph.D., Eli A. Stahl, Ph.D. et al.
Background: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium.