High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial

Journal of the American Geriatrics Society
Volume 65, Issue 3 March 2017 Pages 496–503

Adit A. Ginde MD, MPH, 

Patrick Blatchford PhD, 

Keith Breese MA, 

Lida Zarrabi MPH, Sunny A. Linnebur PharmD,

Jeffrey I. Wallace MD, MPH,
 Robert S. Schwartz MD


To determine the efficacy and safety of high-dose vitamin D supplementation for prevention of acute respiratory infection (ARI) in older long-term care residents.
Randomized controlled trial investigating high-dose vs standard-dose vitamin D from 2010 to 2014.
Colorado long-term care facilities.
Long-term care residents aged 60 and older (n = 107).
The high-dose group received monthly supplement of vitamin D3 100,000 IU, the standard-dose group received a monthly placebo (for participants taking 400–1,000 IU/d as part of usual care) or a monthly supplement of 12,000 I