Hippocampal network abnormalities explain amnesia after VGKCC-Ab related autoimmune limbic encephalitis

Journal of Neurology, Neurosurgery & Psychiatry

Fecha de publicación: 14 August 2019

DOI: http://dx.doi.org/10.1136/jnnp-2018-320168

Autores: Clare Loane, Georgios P D Argyropoulos, Adriana Roca-Fernández, Carmen Lage, Fintan Sheerin, Samrah Ahmed, Giovanna Zamboni, Clare Mackay, Sarosh R Irani, Christopher R Butler.

Background: Limbic encephalitis associated with antibodies to components of the voltage-gated potassium channel complex (VGKCC-Ab-LE) often leads to hippocampal atrophy and persistent memory impairment. Its long-term impact on regions beyond the hippocampus, and the relationship between brain damage and cognitive outcome, are poorly understood. We investigated the nature of structural and functional brain abnormalities following VGKCC-Ab-LE and its role in residual memory impairment.

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