ICARUS study: prevalence and clinical features of impulse control disorders in Parkinson’s disease

Journal of Neurology, Neurosurgery & Psychiatry
Volume 88, Issue 4

Angelo Antonini, Paolo Barone, Ubaldo Bonuccelli, Karin Annoni, Mahnaz Asgharnejad, Paolo Stanzione



Impulse control disorders/other compulsive behaviours (‘ICD behaviours’) occur in Parkinson’s disease (PD), but prospective studies are scarce, and prevalence and clinical characteristics of patients are insufficiently defined.


To assess the presence of ICD behaviours over a 2-year period, and evaluate patients’ clinical characteristics.


A prospective, non-interventional, multicentre study (ICARUS (Impulse Control disorders And the association of neuRopsychiatric symptoms, cognition and qUality of life in ParkinSon disease); SP0990) in treated Italian PD outpatients. Study visits: baseline, year 1, year 2. Surrogate primary variable: presence of ICD behaviours and five ICD subtypes assessed by modified Minnesota Impulsive Disorder Interview (mMIDI).


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