The British Journal of Psychiatry
Fecha de publicación: 23 October 2020
DOI: https://doi.org/10.1192/bjp.2020.163
Autores: Kareen Heinze, Helen C. Barron, Emma K. Howes, Mani Ramaswami and Matthew R. Broome
Background: In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.
