Influence of methodological and patient factors on serum NMDAR IgG antibody detection in psychotic disorders: a meta-analysis of cross-sectional and case-control studies

The Lancet Psychiatry

Fecha de publicación: 21 de diciembre de 2020

DOI: https://doi.org/10.1016/S2215-0366(20)30432-6

Autores: Alexis E Cullen, PhD  ^†, Emma C Palmer-Cooper, PhD ^†, Marc Hardwick, BM, Sophie Vaggers, BA, Hannah Crowley, BA, Thomas A Pollak, PhD, Prof Belinda R Lennox, DM

Background

Antibodies targeting the N-methyl-D-aspartate receptor (NMDAR) have been detected in patients with psychosis. However, studies measuring the IgG subclass in serum have provided variable estimates of prevalence, and it is unclear whether these antibodies are more common in patients than controls. Because these inconsistencies could be due to methodological approaches and patient characteristics, we aimed to investigate the effect of these factors on heterogeneity.