Limbic Hyperactivity in Response to Emotionally Neutral Stimuli in Schizophrenia: A Neuroimaging Meta-Analysis of the Hypervigilant Mind

American Journal of Psychiatry

Fecha de publicación: 6 September 2019


Autores: Jules R. Dugré, M.Sc., Nathalie Bitar, B.Sc., Alexandre Dumais, M.D., Ph.D., Stéphane Potvin, Ph.D.

Background: It has long been assumed that paranoid ideation may stem from an aberrant limbic response to threatening stimuli. However, results from functional neuroimaging studies using negative emotional stimuli have failed to confirm this assumption. One of the potential reasons for the lack of effect is that study participants with psychosis may display aberrant brain responses to neutral material rather than to threatening stimuli. The authors conducted a functional neuroimaging meta-analysis to test this hypothesis.

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