Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre–post studies

The Lancet Psychiatry

Fecha de publicación: 13 de abril de 2021

Autores: Taishiro Kishimoto, MD  ^†, Katsuhiko Hagi, PhD ^†, Shunya Kurokawa, MD, John M Kane, MD, Christoph U Correll, MD

DOI: https://doi.org/10.1016/S2215-0366(21)00039-0

Background: Evidence of comparative benefits of long-acting injectable antipsychotics (LAIs) versus oral antipsychotics for schizophrenia has been inconsistent across study designs. The aim of this study was to evaluate the comparative benefits of LAIs versus oral antipsychotics in three study designs to inform clinical decision making.