Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults
THE AMERICAN JOURNAL OF PSYCHIATRY
Fecha de publicación: 12 Jan 2018
Autores: Nancy J. Donovan, M.D., Joseph J. Locascio, Ph.D., Gad A. Marshall, M.D., Jennifer Gatchel, M.D., Ph.D., Bernard J. Hanseeuw, M.D., Ph.D., Dorene M. Rentz, Psy.D., Keith A. Johnson, M.D., …
Background: To understand the role of depressive symptoms in preclinical Alzheimer’s disease, it is essential to define their temporal relationship to Alzheimer’s proteinopathies in cognitively normal older adults. The study objective was to examine associations of brain amyloid beta and longitudinal measures of depression and depressive symptom clusters in a cognitively normal sample of older adults.