Lower Plasma Klotho Concentrations Are Associated with Vascular Dementia but Not Late-Onset Alzheimer’s Disease


Fecha de publicación: 16 may 2018

DOI: https://doi.org/10.1159/000488318

Autores: Brombo G.a · Bonetti F.a · Ortolani B.a · Morieri M.L.a · Bosi C.a · Passaro A.a · Vigna G.B.a · Borgna C.b · Arcidicono M.V.c,d · Tisato V.d · Zuliani G.e 

Background: The protein Klotho is involved in biological processes related to longevity, cardiovascular health, and cognition. Serum Klotho levels have been associated with better cognition in animal models; moreover, lower Klotho concentrations in cerebrospinal fluid from subjects with late-onset Alzheimer’s disease (LOAD) have been reported.

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