Mediation of the influence of childhood maltreatment on depression relapse by cortical structure: a 2-year longitudinal observational study

The Lancet Psychiatry

Fecha de publicación: 1 April 2019


Autores: Nils Opel, MD., Ronny Redlich, PhD., Katharina Dohm, PhD., Dario Zaremba, MSc., Janik Goltermann, MSc., Jonathan Repple, MD., et al.

Background: Childhood maltreatment is a leading environmental risk factor for an unfavourable course of disease in major depressive disorder. Both maltreatment and major depressive disorder are associated with similar brain structural alterations suggesting that brain structural changes could mediate the adverse influence of maltreatment on clinical outcome in major depressive disorder.

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