Medicines associated with dependence or withdrawal: a mixed-methods public health review and national database study in England

Lancet Psychiatry

Fecha de publicación: 3 October 2019


Autores: Prof John Marsden, PhD., Martin White, MSc., Fizz Annand, PhD., Peter Burkinshaw, BA., Serena Carville, PhD., Brian Eastwood, MSc., et al.

Background: Antidepressants, opioids for non-cancer pain, gabapentinoids (gabapentin and pregabalin), benzodiazepines, and Z-drugs (zopiclone, zaleplon, and zolpidem) are commonly prescribed medicine classes associated with a risk of dependence or withdrawal. We aimed to review the evidence for these harms and estimate the prevalence of dispensed prescriptions, their geographical distribution, and duration of continuous receipt using all patient-linked prescription data in England.

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