Neurological consequences of obesity

The Lancet Neurology
Volume 16, No. 6, p465–477, June 2017

Phillipe D O’Brien, PhD, Lucy M Hinder, PhD, Brian C Callaghan, MD, Dr Eva L Feldman


The high prevalence of obesity is associated with an enormous medical, social, and economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by obesity contribute to the development of a wide variety of disorders and effects on the nervous system. In the CNS, mild cognitive impairment can be attributed to obesity-induced alterations in hippocampal structure and function in some patients. Likewise, compromised hypothalamic function and subsequent defects in maintaining whole-body energy balance might be early events that contribute to weight gain and obesity development…

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