Neuropathology of dementia in patients with Parkinson’s disease: a systematic review of autopsy studies

Journal of Neurology, Neurosurgery & Psychiatry

Fecha de publicación: 23 August 2019


Autores: Callum Smith, Naveed Malek, Katherine Grosset, Breda Cullen, Steve Gentleman, Donald G Grosset.

Background: Dementia is a common, debilitating feature of late Parkinson’s disease (PD). PD dementia (PDD) is associated with α-synuclein propagation, but coexistent Alzheimer’s disease (AD) pathology may coexist. Other pathologies (cerebrovascular, transactive response DNA-binding protein 43 (TDP-43)) may also influence cognition. We aimed to describe the neuropathology underlying dementia in PD.

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