The lancet Neurology
Fecha de publicación: October 05, 2020
DOI: https://doi.org/10.1016/S1474-4422(20)30308-2
Autores: Jakob Matschke, MD, Marc Lütgehetmann, MD, Christian Hagel, MD, Prof Jan P Sperhake, Ann Sophie Schröder, MD, Carolin Edler, MD, et al
Background: Prominent clinical symptoms of COVID-19 include CNS manifestations. However, it is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, gains access to the CNS and whether it causes neuropathological changes. We investigated the brain tissue of patients who died from COVID-19 for glial responses, inflammatory changes, and the presence of SARS-CoV-2 in the CNS.
