No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis
American Journal of Psychiatry
Fecha de publicación: 29 July 2019
Autores: Carolien G.F. de Kovel , Ph.D., Lyubomir Aftanas , M.D., Ph.D., André Aleman , Ph.D., Aaron F. Alexander-Bloch , M.D., Ph.D., Bernhard T. Baune , M.D., Ph.D., Ivan Brack , Ph.D., Robin Bülow , M.D., M.Sc., Geraldo Busatto Filho , M.D., Ph.D., Angela Carballedo , M.D., Colm G. Connolly , Ph.D., et al.
Background: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected.